Fighting retinopathy with repurposed drugs

and another caution for GLP1 agonist drugs. PREMIUM CONTENT subscriber access

The fibrate drug Gemfibrozil (Lopid) [which decreases triglycerides, modestly decreases LDL and increases HDL] also can help to prevent progression of dementia:

“In the beta amyloid field of dementia research, two old drugs may be candidates for repurposing: gemfibrosil, a cholesterol-lowering drug, and retinoic acid, a vitamin A derivative. Encouraging reports from animal studies point to further examination of their effects on brain, especially astrocytes accumulation of the protein. When used in combination, these two drugs show a reversal — instead reduce amyloid beta in the brain, improving cognitive function in mice [5XFAD mouse model of Alzheimer’s disease].”

Now we can report that fibrates also improve diabetic retinopathy.