Liver Learnings: New News on NASH

Vitamins are vital and thyroid hormones, too. PREMIUM CONTENT subscriber access.

Development of NASH from healthy liver. https://www.creative-biolabs.com/nash-therapy/drug-discovery-for-nash-treatment.htm

In a prior newsletter, I reported on breakthrough treatment news for Interstitial Pulmonary Fibrosis. Metformin, thiamine and thyroid hormones all showed beneficial effects as modalities. Now we see progress in the hepatic fibrosis sphere, also by using vitamins and thyroid hormone analogues.

The substrate-overload liver injury model of NASH pathogenesis. (Friedman, 2018). Friedman, S.L.; et al. Mechanisms of NAFLD development and therapeutic strategies. Nature medicine. 2018: 1.

The pathophysiology of NASH is complex and includes multiple parallel hits. NASH is characterized by steatosis as well as hepatocyte injury and inflammation, with or without fibrosis.