Sensory sodium channels: target of new compounds for pain.
Partner proteins modulate the effects. Can they provide relief? PREMIUM CONTENT subscriber access
In a past newsletter I reported on repurposing old drugs to treat acute and chronic pain syndromes. These include probenecid, fluphenazine, and caffeine.
Can we find chronic pain relief using repurposed drugs?
Pain is a problem. BIG problem. It is a research topic pursued relentlessly, but to date, no silver bullet emerges. Yet, I comb the literature, looking for sprouts that may blossom into a potential solution. Recent found works utilize therapeutics that are already approved and commercially available. This news…
In this newsletter, I report on two new discoveries. Their biological mechanism of action utilizes NaV1.7, a voltage-gated sodium ion channel that was linked to pain sensation through the studies of people with rare inherited pain disorders.
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