Sensory sodium channels: target of new compounds for pain.

Partner proteins modulate the effects. Can they provide relief? PREMIUM CONTENT subscriber access

Jul 16, 2023

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stinging hairs — Australian stinging tree injects animals with spider-venom-like toxin . https://www.newscientist.com/article/2254611-australian-stinging-tree-injects-animals-with-spider-venom-like-toxin/

In a past newsletter I reported on repurposing old drugs to treat acute and chronic pain syndromes. These include probenecid, fluphenazine, and caffeine.

Can we find chronic pain relief using repurposed drugs?

BioMedWorks

September 18, 2022

Can we find chronic pain relief using repurposed drugs?

Pain is a problem. BIG problem. It is a research topic pursued relentlessly, but to date, no silver bullet emerges. Yet, I comb the literature, looking for sprouts that may blossom into a potential solution. Recent found works utilize therapeutics that are already approved and commercially available. This news…

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In this newsletter, I report on two new discoveries. Their biological mechanism of action utilizes NaV1.7, a voltage-gated sodium ion channel that was linked to pain sensation through the studies of people with rare inherited pain disorders.

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