Progesterone provides neuroprotection from Parkinson's progression
'Female' hormones helping yet again? PREMIUM CONTENT subscriber access

My past newsletter reported studies of estradiol healing neural injuries:
Estrogen helps heal Traumatic Brain Injury
I started out January with the brain as topic, so let’s keep it rolling along. My previous newsletters discussing aromatase and puberty mentioned estradiol synthesis in the brain from testosterone precursors; now we extend it to talk about its role in healing brain injuries.
Now let us look at that luteal phase ovarian steroid, progesterone (P4). However, do note that P4 is also a steroid generated de novo in brain and retina. In both males and females, it can function as an anesthetic. The anxiolytic and anesthetic effects of progesterone result from its conversion to the metabolite, allopregnanolone.
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