Sleeping pills shut down CSF flow

NE microarousals are brain cleansing vasopumpers. PREMIUM CONTENT subscriber access

Convective glymphatic fluxes of CSF and ISF propel the waste products of neuron metabolism into the paravenous space, from which they are directed into lymphatic vessels and ultimately return to the general circulation for clearance by the kidney and liver.—Maiken Nedergaard. “Garbage Truck of the Brain,” Science 28 June 2013: Vol. 340 no. 6140 pp. 1529-1530; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749839/

The glymphatic system is a brain-wide network responsible for removing protein waste associated with neurodegenerative diseases.

I have reported on this discovery in several past newsletters:

Further facts on glymphatics: Mapping out their passageways

Mobilizing glymph to manage migraine

Keep an eye on ophthalmology

Smell Test as dementia screen and diagnosis, now in clinical practice

Deep Dive into Dementia

And other newsletters looked at the role of norepinephrine in sleep, memory and anesthesia. The micro-architectural organization of NREM sleep, driven by norepinephrine fluctuations and vascular dynamics, is a key determinant for glymphatic clearance.