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designed a cannabinoid molecule with a positive charge, preventing it from crossing the blood-brain barrier into the brain while allowing the molecule to engage CB1 receptors elsewhere in the body.

By modifying the molecule such that it only binds to pain-sensing nerve cells outside of the brain, the researchers achieved pain relief without mind-altering side effects.

Susruta Majumdar, A cryptic pocket in CB1 drives peripheral and functional selectivity, Nature (2025). DOI: 10.1038/s41586-025-08618-7. www.nature.com/articles/s41586-025-08618-7

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