Muscle Mitochondria Misbehaving = Aging?

Does it all come down to ... mitophagy? PREMIUM CONTENT subscriber access

When I wrote my newsletter, Is dialysis a potential fountain of youth?, instead of trying to find magical ingredients from the young blood, they showed that age-reversing effects are possible with only the simple dilution of old mice blood plasma. Turns out it was the dilution of age-accumulated toxins in plasma that could be therapeutic, perhaps by removing factors that could suppress the rebirth of tissues.

Another newsletter, Muscle Miracles? specifically looked at muscle aging. Reduced NAD [mito metabolite/cofactor] content can impair mitochondrial function and thus muscle fiber integrity. This progressive muscle dysfunction is reversed by ingesting the NAD precursor Nicotinamide Riboside. When they prevented the age-related loss of NAD in muscle, they preserved exercise performance. In mice, Stat3 promotes muscle stem cell myogenic lineage progression/differentiation via stimulation of mitochondrial respiration. In young muscle, high levels of Klotho maintain mitochondria, which aids regeneration after injury. Age-related declines of Klotho lead to mitochondrial damage and resultant impaired healing.